Larry Fitzgerald wasn't sweating the curse. He said on the subject before that he doesn't believe in curses, and he makes his own luck. He's not the first guy who said that of the Madden Curse though, and year after year, all have fallen.
On Opening Night- NFL Kickoff, Troy Polamalu (who shares half of the cover for Madden NFL 10, injured his knee and didn't return to the field. Now the speculation is that he could miss anywhere from 3-6 weeks of football with a sprained ligament in his knee.
For those unaware of what exactly the Madden curse is - people believe that players on the cover of Madden get injured the season they're featured. Mike Vick broke his leg, McNabb had a total of 36 injuries (many internal), Ray Lewis fractured his wrist, and Brett Favre tore tendons in his throwing arm. Now the speculation with half of the curse coming true for Polamalu, is that it's just a matter of time before Fitzgerald suffers an injury. But the curse isn't just half complete, it just states that the individual on the cover will get injured, and one of them did, so the curse lives on even if Fitzgerald doesn't get hurt.
But if he does get injured... everyone's eyes will open wider, and more players will probably learn that your luck may be made by yourself, but it gets influenced greatly by other details. So Larry, here's hoping you don't fall victim to the curse as well... good luck!